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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/128/04/0671-0679

    • Keywords

       

      2-aminobenzimidazole; 4-hydroxycoumarin, aldehydes; silane@$TiO_{2}$nanoparticles; benzo[4,5] imidazo[1,2-a]chromeno[4,3-d]pyrimidin-6-one

    • Abstract

       

      A simple, efficient and environmentally benign protocol has been developed for the synthesisof substituted benzo[4,5]imidazo[1,2-a]chromeno[4,3-d]pyrimidin-6-one by a reaction of 4-hydroxycoumarin,aldehydes and 2-aminobenzimidazole using silane@$TiO_{2}$ nanoparticles as heterogeneous catalyst under refluxcondition in ethanol. The surface modification of TiO2 nanoparticles was confirmed by using FT-IR, FE-SEM,EDX, XRD and TEM analyses. Furthermore, the stability of the catalyst was evaluated by thermal gravimetricanalysis (TGA). Some advantages of this method are high yield of products, short reaction time; recyclabilityof the catalyst and column chromatography-free protocol. The synthesized compounds were screened for theirin vitro antioxidant activity and most of the compounds exhibited remarkable antioxidant activity

    • Author Affiliations

       

      VILAS N MAHIRE1 VIJAY E PATEL2 ASHOK B CHAUDHARI1 VIKAS V GITE1 PRAMOD P MAHULIKAR1

      1. School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, India
      2. School of Life Sciences, North Maharashtra University, Jalgaon, Maharashtra, India
    • Dates

       
  • Journal of Chemical Sciences | News

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