Synthesis, characterization, X-ray crystal structure, electrochemical evaluation and anti-cancer studies of a mixed ligand Cu(II) complex of (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide
Iran Sheikhshoaie S Yousef Ebrahimipour Mahdieh Sheikhshoaie Maryam Mohamadi Mehdi Abbasnejad Hadi Amiri Rudbari Giuseppe Bruno
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A ternary mixed ligand Cu(II) complex, [Cu(L)(Phen)], was prepared from the reaction of (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide [HL], Cu(NO3)2.3H2O and 1,10-Phenanthroline in 1:1:1 molar ratio. This complex was fully characterized using spectroscopic and physicochemical methods. The structure of the complex was determined by single crystal X-ray diffraction. The Cu(II) center is coordinated by two oxygen and one nitrogen donors of L2− and nitrogen atoms of the heterocyclic group. Electrochemical studies of the Cu(II) complex showed shifts in the ligand peaks as well as the appearance of new peaks after complexation. The electrochemical behavior of the Cu(II) complex was also studied using cyclic voltammetry. According to biochemical investigation (MCF-7 cells viability), anticancer activity of [Cu(L)(Phen)] was higher than those of Cu(NO3)2.3H2O, HL and 1,10-Phenanthroline.
Iran Sheikhshoaie1 S Yousef Ebrahimipour1 Mahdieh Sheikhshoaie1 Maryam Mohamadi1 2 Mehdi Abbasnejad3 Hadi Amiri Rudbari4 Giuseppe Bruno5
Volume 135, 2023
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