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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/127/12/2183-2191

    • Keywords

       

      Silver nanoparticle; radical scavenging efficacy; Thiol; DPPH.

    • Abstract

       

      Radical scavenging efficacy of L-cysteine (L-Cys), glutathione (GSH) and thioctic acid (TA) in the presence of silver nanoparticles (AgNPs) were determined by 1,1-diphenyl 2-picryl hydrazil (DPPH), nitric oxide (NO) and hydroxyl (OH) radicals as spectrophotometric assay. The hydrogen peroxide (H2O2) scavenging efficacy has been determined by titration method. Ascorbic acid has been used as standard for all radical scavenging efficacies. In general, antioxidant activity decreases in the presence of AgNPs. The covalent interactions of thiols (-SH) were found to be a key factor for the decreases in scavenging activity. The effect of thiol concentrations has been discussed. The size and shape of the nanoparticles and AgNP-SR interactions have been characterized through Transmission Electron Microscopy (TEM) and Fourier Transform Infrared (FTIR) spectroscopy, respectively.

    • Author Affiliations

       

      Kumudini Chandraker1 Sandeep Kumar Vaishanav1 Rekha Nagwanshi2 Manmohan L Satnami1

      1. School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur 492 010, India
      2. Department of Chemistry, Govt. Madhav Science P. G. College, Ujjain (M.P.), 456 010 India

    • Dates

       
      Published
      December 2015
      Manuscript received
      10 July 2015
      Manuscript revised
      26 August 2015
      Accepted
      11 September 2015

    • Supplementary Material

       

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