• Aggregation properties of levofloxacin in water and ethanol and its interaction with sodium dodecyl sulphate: A thermodynamic study

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    • Keywords


      Levofloxacin; solubilization; micellization; UV/Visible spectroscopy; partition coefficient.

    • Abstract


      This manuscript reports the determination of critical micelle concentration (CMC) of levofloxacin (LF) in two solvents, water and ethanol, by using surface tension, refractive index and absorbance measurements. The data thus obtained were used to calculate different thermodynamic parameters for micellization process like free energy of micellization, free energy of adsorption, entropy and enthalpy of micellization. The interaction of this drug with anionic surfactant (SDS) was also studied using UV/Visible spectroscopy and conductometry. With rise in temperature, CMC of the drug was found to decrease in ethanol and increase in aqueous solution indicating dominance of lipophobic desolvation over lipophilic desolvation in ethanol and reverse, in case of aqueous solution. A strong drug/surfactant interaction was found to exist. The data obtained from drug/surfactant interaction were also used to find different interaction parameters like partition constant, free energy of partition, binding constant and free energy of binding which are very useful to understand the phenomenon of solubilization.

    • Author Affiliations


      Muhammad Shakeel1 Khalid Mehmood1 Mohammad Siddiq2

      1. Department of Chemistry, Hazara University, Mansehra 21300 (KPK), Pakistan
      2. Department of Chemistry, Quaid-e-Azam University, Islamabad 45320, Pakistan
    • Dates

  • Journal of Chemical Sciences | News

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