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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/127/11/2023-2028

    • Keywords

       

      Latanoprost; Corey lactone diol; Swern oxidation; Allylic reduction; Wittig reaction.

    • Abstract

       

      An efficient asymmetric synthetic route for the synthesis of anti-glaucoma agent, (15R)-latanoprost using Corey lactone diol as chiral substrate under Swern oxidation, allylic reduction and Wittig reaction conditions has been developed. In this method, reduction of keto and alkene functional groups has been achieved in a single step using low cost catalyst NiCl2/NaBH4 in methanol. This new synthetic protocol is a good alternative for the synthesis of latanoprost with high stereo selectivity and improved yield.

    • Author Affiliations

       

      K Vijendhar1 2 B Srinivas2 Sathyanarayana Boodida1

      1. Department of Chemistry, JNTUH College of Engineering Jagtial, Karimnagar 505 501, India
      2. R&D Division, Aspen Bio Pharma Labs Pvt. Ltd, Genome Vally, Turkapally, Hyderabad 500 078, India

    • Dates

       
      Published
      November 2015
      Manuscript received
      29 June 2015
      Manuscript revised
      1 September 2015
      Accepted
      3 September 2015

    • Supplementary Material

       

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