• Synthesis of Novel 5-(𝑁-Substituted-Anilino)-8-Hydroxyquinolines via Hartwig-Buchwald Amination Reaction

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    • Keywords


      Hartwig–Buchwald amination; electron-rich phosphine ligands; 5-anilino-8-hydroxyquinoline; 1,2,3,4-tetrahydroquinolin-8-ol; catalytic hydrogenation.

    • Abstract


      Three novel 5-(𝑁-substituted-anilino)-8-benzyloxyquinoline derivatives were efficiently synthesized via Hartwig–Buchwald amination reaction. The new 5-(𝑁-substituted-anilino)-8-benzyloxyquinolines were reduced for 1–3 h to give the corresponding 5-(𝑁-substituted-anilino)-8-hydroxyquinolines. Extending the reduction reaction time to 7 h afforded the corresponding 1,2,3,4-tetrahydro-8-hydroxyquinoline derivatives.

    • Author Affiliations


      Walaa A E Omar1 2 Osmo E O Hormi1

      1. Department of Chemistry, University of Oulu, P.O. Box 3000, FI-90014 Oulu, Finland
      2. Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt
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  • Journal of Chemical Sciences | News

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