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      https://www.ias.ac.in/article/fulltext/jcsc/127/11/1883-1893

    • Keywords

       

      Nickel(II) complexes; N2S2 donor set; crystal structures; biological study.

    • Abstract

       

      A series of neutral hexacoordinated nickel(II) complexes of formula [NiII (L)X2] (where L = 3,4-bis(2-pyridylmethylthio)toluene with tetradentate N2S2 donor set and X = chloride (1), azide (2), cyanate (3) and isothiocyanate anion (4)) have been synthesized and isolated in pure form. The complexes were characterized by physicochemical and spectroscopic methods along with detailed structural characterization of 1,2 and 3 by single crystal X-ray diffraction analyses. The structural study showed that the nickel(II) ion has a distorted octahedral geometry being chelated by the tetradentate N2S2 ligand and bound to cis- located choride or pseudohalide anions. In dimethylformamide solution the complexes showed quasi-reversible NiII/NiIII redox couples in cyclic voltammograms with E1/2 values of +0.723, +0.749, +0.768 and +0.868 V for 1, 2, 3 and 4, respectively. The study of interaction of the complexes with calf thymus DNA, bovine serum albumin (BSA) and human serum albumin (HSA) using spectroscopic and physicochemical tools clearly indicates that the complexes interact with DNA via groove binding mode.

    • Author Affiliations

       

      Animesh Patra1 Biplab Mondal1 Buddhadeb Sen1 Ennio Zangrando2 Pabitra Chattopadhyay1

      1. Department of Chemistry, Burdwan University, Golapbag, Burdwan 713 104, India
      2. Department of Chemical and Pharmaceutical Sciences, Via Licio Giorgieri 1, 34127 Trieste, Italy
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    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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