• Synthesis, structural characterization and biological activities of organotin(IV) complexes with 5-allyl-2-hydroxy-3-methoxybenzaldehyde-4-thiosemicarbazone

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      https://www.ias.ac.in/article/fulltext/jcsc/127/09/1589-1597

    • Keywords

       

      4-thiosemicarbazone; Organotin(IV) complexes; synthesis; characterization; crystal structure; antibacterial activity.

    • Abstract

       

      The organotin(IV) complexes [MeSnCl(L)] (2), [BuSnCl(L)] (3), [PhSnCl(L)] (4) and [Me2Sn(L)] (5) were synthesized by reacting organotin(IV) chloride(s) with 5-allyl-2-hydroxy-3-methoxybenzaldehyde- 4-thiosemicarbazone [H2L], (1)] in presence of KOH in 1:2:1 molar ratio (metal salt: base:ligand). All the complexes have been characterized by elemental analyses, UV-Vis, FT-IR, 1H, 13C and 119Sn NMR spectral studies. The molecular structure of complex 5 has been confirmed by single crystal X-ray diffraction analysis. The ligand, H2L coordinates to Sn(IV) in thiolate form through phenoxide-O, azomethine-N and thiolate-S atoms. The C-Sn-C angle measured from coupling constant 1𝐽 (119Sn, 13C) for dimethyltin(IV) complex 5 is 123.4°. The 2𝐽 (119Sn, 1H) coupling constant values for complex 2 and 5 are 72.4 and 76.3 Hz, respectively. Proposed geometry for five coordinated Sn(IV) atom is a strongly distorted trigonal bipyramid. Biological studies were preformed in vitro against four bacterial strains which have shown better activities and potential as antibacterial agents.

    • Author Affiliations

       

      Rosenani A Haque1 M A Salam1

      1. The School of Chemical Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia
    • Dates

       
  • Journal of Chemical Sciences | News

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