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    • Keywords


      Brønsted acid; ionic liquid; 1,2,4-Triazolium triflate; Biginelli reaction; Pyrimidones.

    • Abstract


      Synthesis of three Brønsted acid-based ionic liquids, namely, 1-ethyl-1,2,4-triazolium triflate (1a), 1-propyl-1,2,4-triazolium triflate (1b) and 1-butyl-1,2,4-triazolium triflate (1c), is described. These ionic liquids have been employed as catalysts for convenient and high-yielding one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones, which are Biginelli reaction products. Advantages of the methodology are operational convenience, short reaction times, avoidance of chromatographic purification and non-production of toxic waste. Further, the catalysts are easily recovered and reused without any noticeable diminution in their catalytic activity.

    • Author Affiliations


      Sankaranarayanan Nagarajan1 Tanveer M Shaikh1 Elango Kandasamy1

      1. Department of Chemistry, Vel Tech University, Chennai 600 062, India
    • Dates

  • Journal of Chemical Sciences | News

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