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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/127/08/1417-1426

    • Keywords

       

      Bis-MBH adduct; Oxindole; Nucleophilic substitution; Tri-substituted olefins; bis-pyrazole.

    • Abstract

       

      An efficient and facile synthesis of divergent C-3/C-5 bis-functionalized 2-oxindole derivatives has been achieved from 3,5-bis-Morita-Baylis-Hillman (MBH) adducts of oxindole via nucleophilic substitution reaction for the first time. Wider scope of substrate and rate acceleration has been observed in second MBH reaction under typical reaction condition. The synthetic usefulness of bi-functionalized bis-allyl derivative has been demonstrated by the synthesis of potent bis-pyrazole via [3+2]-annulation strategy.

    • Author Affiliations

       

      Kodirajan Selvakumar1 Kandapalam Arun Prasath Lingam2 Rama Varma Luxmi Varma3 Poovan Shanmugavelan4

      1. Department of Chemistry, Thiagarajar College, Madurai 625 009, Tamil Nadu, India
      2. Department of Chemistry, Kamaraj College, Tuticorin 628 003, Tamil Nadu, India
      3. Chemical Sciences and Technology Division, National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695 019, Kerala, India
      4. Department of Chemistry, School of Science, Tamilnadu Open University, Saidapet, Chennai 600 015, Tamil Nadu, India

    • Dates

       
      Published
      August 2015
      Manuscript received
      27 November 2014
      Manuscript revised
      13 May 2015
      Accepted
      14 May 2015

    • Supplementary Material

       

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