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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/127/08/1375-1381

    • Keywords

       

      Nickel(II); Schiff base; crystal structure; DNA cleavage

    • Abstract

       

      Synthesis and characterization of a mononuclear Ni(II) compound [Ni(L)(H2O)2](NO3)2 [L = N,N'-bis((pyridine-2-yl)phenylidene)-1,3-diaminopropan-2-ol] (1) is reported. 1 crystallizes in triclinic P-1 space group with a = 8.1911(2) Å, b = 11.6624(3) Å, c = 16.5356(4) Å and𝛼 = 108.8120(10)° , 𝛽 = 91.2010(10)° , 𝛾 = 91.1500(10)° . The binding property of the complex with DNA has been investigated using absorption and emission studies, and viscosity experiment. The binding constant (Kb) and the linear Stern-Volmer quenching constant (Ksv) of the complex have been determined as 9.23 × 10 4 M−1 and 2.0 × 10 4 M−1, respectively. Spectroscopic and hydrodynamic investigations revealed groove or electrostatic nature of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner.

    • Author Affiliations

       

      Sarat Chandra Kumar1 Abhijit Pal1 Merry Mitra1 V M Manikandamathavan2 Chia -Her Lin3 Balachandran Unni Nair2 Rajarshi Ghosh1

      1. Department of Chemistry, The University of Burdwan, Burdwan 713 104, India
      2. Chemical Laboratory, Central Leather Research Institute, Adyar, Chennai 600 020, India
      3. Department of Chemistry, Chung Yuan Christian University, Chung Li, Taiwan 32023, ROC

    • Dates

       
      Published
      August 2015
      Manuscript received
      26 December 2014
      Manuscript revised
      16 April 2015
      Accepted
      27 April 2015

    • Supplementary Material

       

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