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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/127/06/1047-1052

    • Keywords

       

      Biginelli reaction; Tris(pentafluorophenyl)borane; multicomponent reaction; dihydropyrimidinone; dihydropyrimidinthione.

    • Abstract

       

      Tris(pentafluorophenyl)borane catalyzed, one-pot, simple, efficient and environmentally benign protocol for the synthesis of dihydropyrimidinones/thiones via Biginelli reaction has been described. The main highlights of the present protocol is low catalyst loading, low toxicity, compatibility with acid-labile-protecting groups, short reaction time, consistently excellent yields and simple reaction/workup procedure. Moreover, the applicability of the present methodology for large-scale synthesis of monastrol highlights its potential for bulk synthesis.

    • Author Affiliations

       

      Santosh Kumar Prajapti1 Keshav Kumar Gupta1 Bathini Nagendra Babu1

      1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad 500 037, India
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    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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