• Nano-TiCl4/SiO2: An efficient heterogeneous solid acid catalyst for the one pot cascade five-component synthesis of densely functionalized tetrahydropyridines

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      https://www.ias.ac.in/article/fulltext/jcsc/127/05/0885-0895

    • Keywords

       

      Tetrahydropyridines; Nano-TiCl4/SiO2; heterogeneous catalyst; five-component reaction; onepot synthesis.

    • Abstract

       

      Nano-TiCl4/SiO2 was found to be an inexpensive and efficient heterogeneous solid acid catalyst for the synthesis of one-pot cascade synthesis of highly functionalized asymmetric tetrahydropyridines from the five-component condensation reaction of the para-substituted anilines and aromatic aldehydes with ethyl acetoacetate under thermal conditions. Novel methodology, environmentally benign conditions, clean protocol, easy work-up and high yields are the important advantages of this protocol. The products were characterized using physical and spectroscopic data such as FT-IR, 1H-NMR and in some cases 13C-NMR and CHN analysis.

    • Author Affiliations

       

      Abdolhamid Bamoniri1 Bi Bi Fatemeh Mirjalili2 Reza Tarazian1

      1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran
      2. Department of Chemistry, College of Science, Yazd University, Yazd, I. R. Iran
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