Syntheses of fused tetrahydro-𝛽-carboline analogues through imide carbonyl activation using BBr3: Evidence for the involvement of fused cyclic 𝑁-acyliminium ion intermediate
The fused cyclic 𝑁-acyliminium ion generated during the imide carbonyl activation reaction of phenethylphthalimide was confirmed by single crystal X-ray diffraction. The Lewis acid assisted imide carbonyl activation methodology was successfully extended to synthesize fused tetrahydro-𝛽-carboline units from the corresponding 𝑁-indolylethylimides.
Volume 134, 2022
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