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    • Keywords


      Reductive amination; Lewis acid; tris(pentafluorophenyl)borane; sodium borohydride; less-toxic; tandem reaction.

    • Abstract


      An efficient combination of B(C6F5)3 and NaBH4 was developed for direct reductive amination of aldehydes. A wide range of functional groups such as ester, nitro, nitrile, halogen, alkene, heterocycles were tolerated. Also, acid sensitive protecting groups like TBDMS and TBDPS were not affected. In addition, the present methodology was extended for tandem amination-amidation of 3-formyl-indole-2-carboxylic acids with substituted anilines to afford 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-ones.

    • Author Affiliations


      Atulya Nagarsenkar1 Santosh Kumar Prajapti1 Nagendra Babu Bathini1

      1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad 500037, India
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    • Supplementary Material

  • Journal of Chemical Sciences | News

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