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      https://www.ias.ac.in/article/fulltext/jcsc/127/04/0649-0661

    • Keywords

       

      Cobalt(III); X-ray structure; Catecholase activity; DNA cleavage; Anti-cancer activity.

    • Abstract

       

      We have synthesized two isostructural mononuclear cobalt(III) complexes [1]NO3·3H2O and [1]NO3·CH3CO2H·H2O {[1]+ = [Co(1,10-phenanthroline)2Cl2]+} and characterized by single crystal X-ray structural analyses. Mass spectral studies of the complexes indicate both the compounds to produce identical cationic species viz., [Co(phen)2Cl2]+ in methanol solution. [1]+ has been evaluated as model system for the catechol oxidase enzyme by using 3,5-di-tert-butylcatechol (3,5-DTBC) as the substrate in methanol medium, which revealed that the cationic complex efficiently inhibits catalytic activity with kcat value 9.65 × 102 h−1. [1]+ cleaved pBR 322 DNA without addition of an activating agent. Further, the anti-cancer activity of [1]+ on human hepatocarcinoma cell line (HepG2) has been examined. The induction of apoptosis induced in the cell line was assessed base on the changes in cell morphology, which showed the efficacy of [1]+ to induce apoptosis in 53% of cells during 24 h treatment. Interestingly, the observed IC50 values reveal that [1]+ brings about conformational change on DNA strongly and exhibits remarkable cytotoxicity.

    • Author Affiliations

       

      Dhananjay Dey1 Arnab Basu Roy1 Anandan Ranjani2 Loganathan Gayathri2 Saravanan Chandraleka2 3 Dharumadurai Dhanasekaran2 Mohammad Abdulkader Akbarsha4 Chung-Yu Shen5 Hui-Lien Tsai5 Milan Maji6 Niranjan Kole1 Bhaskar Biswas1

      1. Department of Chemistry, Raghunathpur College, Purulia 723133, India
      2. Department of Microbiology, Bharathidasan University, Tiruchirappalli 620 024, India
      3. Department of Chemistry, Urumu Dhanalakshmi College, Tiruchirappalli 620019, India
      4. Mahatma Gandhi-Doerenkamp Centre, Bharathidasan University, Tiruchirappalli 620 024, India
      5. Department of Chemistry, National Cheng Kung University, Tainan City, 70101, Taiwan
      6. Department of Chemistry, National Institute of Technology, Mahatma Gandhi Avenue, Durgapur 713209, India
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