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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/127/03/0467-0479

    • Keywords

       

      Thiazolo[3,2−a]pyrimidines; hydrolysis of arylidene derivative; crystal structure; anti-microbial activity.

    • Abstract

       

      A new ammonium acetate-assisted, convenient and efficient procedure for the synthesis of arylidene derivatives of thiazolopyrimidine is described. The main advantages of this protocol is that it is economical, short reaction time, commonly available chemicals, and ease of isolation of products. In addition, a new series of thiazole-fused pyrimidines were synthesized and hydrolysis of one of its arylidene derivative studied. All the compounds were characterized by analytical and spectroscopic methods. Further, the structure of hydrolyzed product and two other compounds were confirmed by X-ray crystal structure analysis. The crystal structures are stabilized by intermolecular C-H...O, C-H...N, C-H... 𝜋 and 𝜋 ...𝜋 weak interactions. The anti-microbial screening was done on the compounds in order to test their anti-bacterial and anti-fungal activities.

    • Author Affiliations

       

      H Nagarajaiah1 Imtiyaz Ahmed M Khazi2 Noor Shahina Begum1

      1. Department of Chemistry, Bangalore University, Central College Campus, Bangalore 560001, India
      2. Department of Chemistry, Karnatak University, Dharwad 580003, India

    • Dates

       
      Published
      March 2015
      Manuscript received
      16 May 2014
      Manuscript revised
      12 September 2014
      Accepted
      7 October 2014

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