• Ultrasound promoted and SiO2/CCl3COOH mediated synthesis of 2-aryl-1-arylmethyl-1𝐻-benzimidazole derivatives in aqueous media: An eco-friendly approach

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      https://www.ias.ac.in/article/fulltext/jcsc/126/06/1831-1840

    • Keywords

       

      2-Aryl-1-arylmethyl-1H-benzimidazoles; silica gel supported trichloroacetic acid (SiTCA); regioselective; one-pot synthesis; ultrasound irradiation.

    • Abstract

       

      Ultrasonic irradiation is an efficient and innocuous technique of reagent activation for synthesizing organic compounds. First one-pot synthesis of 2-aryl-1-arylmethyl-1H- benzimidazole derivatives from o- phenylenediamine and an aromatic aldehyde in the presence of silica gel supported trichloroacetic acid (SiTCA) was carried out with excellent yields at 50°C by sonication. This method provided several advantages such as green solvent, inexpensive catalyst, simple experimental methodology, shorter reaction time and higher yield.

    • Author Affiliations

       

      Brajesh Kumar1 2 Kumari Smita2 Brajendra Kumar3 Luis Cumbal2

      1. Department of Chemistry, TATA College, Kolhan University, Chaibasa, Jharkhand, 833 202, India
      2. Centro de Nanociencia y Nanotecnologia, Universidad de las Fuerzas Armadas -ESPE, Av. Gral. Rumiñahui s/n, Sangolqui, P.O. BOX 171-5-231B, Ecuador
      3. Department of Computer Science and Engineering, National Institute of Technology, Durgapur, West Bengal, 713 209, India
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