• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/126/04/1115-1124

    • Keywords

       

      Metallorganic framework (MOF); dysprosium complex; crystal structure; DNA binding; BSA binding.

    • Abstract

       

      A dysprosium-based metallo-organic framework (MOF) containing calcium ions formulated as {Dy(pyda)3Ca1.5(H2O)6} · 5.5H2O (1) (H2pyda = pyridine-2,6-dicarboxylic acid) was solvothermally synthesized in ethanolic medium and characterized by physico-chemical and spectroscopic tools. A detailed structural analysis of the solid state structure of 1 by single crystal X-ray diffraction study showed a tricapped trigonal prism geometry for lanthanide in the [Dy(pyda)3]3− fragment. The mode of interaction of 1 with calf thymus- DNA and with protein bovine serum albumin (BSA) was investigated by using absorption and emission spectroscopic tools. The apparent association constant of complex 1 with CT-DNA was deduced from an absorption spectral study ($K_b = 4.08 \times 10^4$ M-1). Spectral and viscosity measurements indicated a groove-binding mode of 1 with CT-DNA, and from spectroscopic study the formation of a metal complex-BSA adduct was assumed to be the result of the interaction of 1 with BSA.

    • Author Affiliations

       

      Biplab Mondal1 Buddhadeb Sen1 Ennio Zangrando2 Pabitra Chattopadhyay1

      1. Department of Chemistry, Burdwan University, Golapbag, Burdwan 713104, India
      2. Department of Chemical and Pharmaceutical Sciences, Via Licio Giorgieri 1, 34127 Trieste, Italy
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

© 2022-2023 Indian Academy of Sciences, Bengaluru.