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    • Keywords


      N-benzylpiperidin-4-one oximes; cytotoxicity, HeLa cells; single-crystal XRD.

    • Abstract


      A series of fifteen diversified N-benzylpiperidin-4-one oximes were synthesized and characterized by their NMR spectral data. Additionally, single-crystal XRD analysis was performed for the representative symmetrically and unsymmetrically substituted molecules. All the synthesized oximes from unsymmetrical ketones existed as E-isomer as witnessed by their NMR and XRD data. Among the synthesized target compounds that evaluated for their in vitro cytotoxicity against human cervical carcinoma (HeLa) cells, five compounds were potent with IC50 < 17 𝜇M. 1-Benzyl-2,6-bis(4-isopropylphenyl)-3-methylpiperidin-4-one oxime 3c with an IC50 of 13.88 𝜇M was found to be the best active compound as depicted by the microscopic analysis.

    • Author Affiliations


      Someshwar D Dindulkar1 2 Ira Bhatnagar3 Rupesh L Gawade4 Vedavati G Puranik4 Se-Kwon Kim1 Dong Hyun Anh5 Paramasivam Parthiban6 Yeon Tae Jeong1

      1. Department of Image Science and Engineering, Pukyong National University, Busan 608 737, Republic of Korea
      2. Institute of MGM’s Jawaharlal Nehru Engineering College, Aurangabad, 431 003, India
      3. Nanotheranostics Laboratory, Centre for Cellular and Molecular Biology, Hyderabad 500 007, India
      4. Center for Materials Characterization, National Chemical Laboratory, Pune 400 008, India
      5. Department of Food Science and Technology, Pukyong National University, Busan 608 737, Republic of Korea
      6. Department of Chemistry, Veltech Multitech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai 600 062, India
    • Dates

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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