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    • A concise and simple synthesis of 1-hydroxy-phenethylamine derivatives: Formal synthesis of naturally occurring norephedrine, virolin and 3-hydroxy-2-phosphonylmethoxypropyl adenine

      S Saha P Chakraborty S C Roy

      Regular Articles Volume 126 Issue 3 May 2014 pp 837-846

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/126/03/0837-0846

    • Keywords

       

      Synthesis; 1-hydroxy-phenethylamine derivatives; intermediates; bio-active; small molecules.

    • Abstract

       

      A concise and simple synthesis of 1-hydroxy-phenethylamine derivatives has been achieved following classical organic transformations using commercially available chiral pools. The said derivatives were explored for the synthesis of naturally occurring bio-active small molecules. Formal synthesis of norephedrine, virolin and 3-hydroxy-2-phosphonylmethoxypropyl adenine has been demonstrated.

    • Author Affiliations

       

      S Saha1 2 P Chakraborty1 S C Roy1

      1. Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
      2. Department of Chemistry, National Institute of Technology, Sikkim 739 139, India

    • Dates

       
      Published
      May 2014
      Manuscript received
      25 November 2013
      Manuscript revised
      21 January 2014
      Accepted
      11 January 2014

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