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https://www.ias.ac.in/article/fulltext/jcsc/126/03/0837-0846

Synthesis; 1-hydroxy-phenethylamine derivatives; intermediates; bio-active; small molecules.

A concise and simple synthesis of 1-hydroxy-phenethylamine derivatives has been achieved following classical organic transformations using commercially available chiral pools. The said derivatives were explored for the synthesis of naturally occurring bio-active small molecules. Formal synthesis of norephedrine, virolin and 3-hydroxy-2-phosphonylmethoxypropyl adenine has been demonstrated.

S Saha^{1 2} P Chakraborty¹ S C Roy¹

1. Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
2. Department of Chemistry, National Institute of Technology, Sikkim 739 139, India

Published

May 2014

Manuscript received

25 November 2013

Manuscript revised

21 January 2014

Accepted

11 January 2014