• A concise and simple synthesis of 1-hydroxy-phenethylamine derivatives: Formal synthesis of naturally occurring norephedrine, virolin and 3-hydroxy-2-phosphonylmethoxypropyl adenine

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      https://www.ias.ac.in/article/fulltext/jcsc/126/03/0837-0846

    • Keywords

       

      Synthesis; 1-hydroxy-phenethylamine derivatives; intermediates; bio-active; small molecules.

    • Abstract

       

      A concise and simple synthesis of 1-hydroxy-phenethylamine derivatives has been achieved following classical organic transformations using commercially available chiral pools. The said derivatives were explored for the synthesis of naturally occurring bio-active small molecules. Formal synthesis of norephedrine, virolin and 3-hydroxy-2-phosphonylmethoxypropyl adenine has been demonstrated.

    • Author Affiliations

       

      S Saha1 2 P Chakraborty1 S C Roy1

      1. Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
      2. Department of Chemistry, National Institute of Technology, Sikkim 739 139, India
    • Dates

       
  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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