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      https://www.ias.ac.in/article/fulltext/jcsc/126/03/0739-0749

    • Keywords

       

      Ruthenium; fluoroquinolone; LC50; partial intercalation; HS DNA.

    • Abstract

       

      Six new Ru(II) and Ru(III) complexes have been synthesized and characterized by elemental analysis, LC-MS, electronic spectra, IR spectra and magnetic moment measurements. DNA-binding properties of Ru complexes have been studied by means of absorption spectrophotometry and viscosity measurements as well as their HS DNA cleavage properties by means of agarose gel electrophoresis. The experimental results show that all the complexes can bind to DNA via partial intercalative mode. The $K_b$ values of complexes were found in the range $2.14 \times 10^4$ to $2.70 \times 10^5$ M-1. All the complexes show excellent efficiency of cleaving DNA than respective fluoroquinolones. Brine shrimp lethality bioassay has been performed to check the cytotoxic activity. The IC50 values of the complexes are in the range of 6.27 to 16.05 𝜇g mL-1.

    • Author Affiliations

       

      Mohan N Patel1 Hardik N Joshi1 Chintan R Patel1

      1. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, India
    • Dates

       
    • Supplementary Material

       
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