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    • The family of N9-adenine: New entry for adenine-benzamide conjugates linked via versatile spacers

      Prabhpreet Singh

      Volume 126 Issue 1 January 2014 pp 159-167

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/126/01/0159-0167

    • Keywords

       

      Nucleobase; substituted benzamide; adenine; triethyleneglycol; aminocaproic acid.

    • Abstract

       

      We have prepared 4-nitrobenzamide-adenine conjugates (8, 13 and 14) linked with versatile spacer such as triethylene glycol (TEG), aminocaproic acid and ethyl chains which were eventually reduced to obtain the corresponding 4-aminobenzamide-adenine conjugates (1-3) in good yields. These conjugates bear a nucleobase for DNA recognition or self-assembly through base-pair complementarity, a biocompatible linker for interfacing with biological system, and a p-aminobenzamide moiety for pharmacological applications. The use of hydrophilic or lipophilic linkers may tune the dispersibility of these conjugates in different solvents, as well as impart different properties. In the preliminary experiments the versatility and application of these linkers has been tested for functionalization of SWCNTs.

    • Author Affiliations

       

      Prabhpreet Singh1

      1. Department of Chemistry, UGC Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143 005, India

    • Dates

       
      Published
      January 2014
      Manuscript received
      6 September 2013
      Manuscript revised
      31 October 2013
      Accepted
      10 November 2013

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