• Signal amplification of dopamine using lanthanum hexacyanoferrate-modified electrode

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      https://www.ias.ac.in/article/fulltext/jcsc/126/01/0011-0016

    • Keywords

       

      Lanthanum hexacyanoferrate-modified electrode; dopamine; ascorbic acid; signal amplification; real sample analysis.

    • Abstract

       

      A sensitive and selective electrochemical sensor has been developed using an electroactive polynuclear lanthanum hexacyanoferrate (LaHCF) complex with counter alkali cation (Na+) deposited on the glassy carbon (GC) electrode (GC/LaHCF). The GC/LaHCF-modified electrode is found to be an excellent transducer in mediating the oxidation of neurotransmitter molecule such as dopamine (DA) at physiological pH 7.2. Interestingly, the GC/LaHCF-modified electrode amplifies a 50-fold enhancement in the oxidation of DA signal compared to the bare GC electrode. Besides, the GC/LaHCF-modified electrode shows excellent selectivity in the voltammetric oxidation of DA in the presence of ascorbic acid (AA). Under optimal conditions, the GC/LaHCF modified electrode shows a linear relationship in DA oxidation between $0.1 \times 10^{−6}$ and $1.0 \times 10^{−6}$M with the detection limit of $1 \times 10^{−8}$M (10 nM). Importantly, practical utility of the modified electrode is good in studying the real sample analysis such as dopamine hydrochloride injection assay.

    • Author Affiliations

       

      T Selvaraju1 2 R Ramaraj1

      1. Centre for Photoelectrochemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India
      2. Department of Chemistry, Karunya University, Coimbatore 641 114, India
    • Dates

       
  • Journal of Chemical Sciences | News

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