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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/125/06/1555-1571

    • Keywords

       

      𝛽-keto ester; 𝛼-alkoxy acid; PPAR; partial agonism.

    • Abstract

       

      The design and synthesis of benzimidazolyl and indolyl linked 𝛼-alkoxy phenylpropanoic acid derivatives and the 𝛽-keto ester analogues in an effort to develop novel peroxisome proliferator activated receptors ligands expected to exhibit PPAR𝛼 and PPAR𝛾 partial agonism in the management of hyperglycemia and hyperlipidemia for the treatment of type 2 diabetes is reported. Computational validation of the designed molecules through activity prediction and docking studies showed expected results.

    • Author Affiliations

       

      Raman K Verma1 Prithwish Ghosh1 Vijay Kumar1 Lalit K Wadhwa2

      1. Synthetic Organic and Medicinal Chemistry Laboratory, Department of Chemistry, Punjabi University, Patiala 147 002, India
      2. Ind-Swift Laboratories Limited (Research and Development Centre), Plot No. E-5, Industrial Area, Phase-2, SAS Nagar, Mohali 160 055, India

    • Dates

       
      Published
      November 2013
      Manuscript received
      28 June 2012
      Manuscript revised
      15 March 2013
      Accepted
      4 July 2013

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