• Zn(OTf)2-catalysed indolylation and pyrrolylation of isatins: Efficient synthesis and biochemical assay of 3,3-di(heteroaryl)oxindoles

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      https://www.ias.ac.in/article/fulltext/jcsc/125/06/1543-1553

    • Keywords

       

      Zn(OTf)2; 3,3-di(indolyl)oxindoles; 3,3-di(pyrrolyl)oxindoles; serum glutamate oxaloacetate transaminase (SGOT); malondialdehyde (MDA).

    • Abstract

       

      An efficient and cheap synthetic approach to 3,3-di(indolyl)oxindoles and 3,3-di(pyrrolyl) oxindoles has been developed via Zn(OTf)2 catalysed indolylation and pyrrolylation of isatins. A preliminary biochemical assay of the synthesized molecules in rodent models were performed to estimate the serum glutamate oxaloacetate transaminase and malondialdehyde levels.

    • Author Affiliations

       

      C Praveen1 S Narendiran2 P Dheenkumar1 3 P T Perumal1

      1. Organic Chemistry Division, Central Leather Research Institute (CSIR), Adyar, Chennai 600 020, India
      2. Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chitoor 517 127, India
      3. Department of Pharmaceutical Chemistry, EGS Pillay College of Pharmacy, Nagapattinam 611 002, India
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