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      https://www.ias.ac.in/article/fulltext/jcsc/125/05/1161-1168

    • Keywords

       

      Iron(II); Schiff base; X-ray structure; DNA binding; DNA cleavage.

    • Abstract

       

      Synthesis and characterization of a mononuclear Fe(II) compound [Fe(L)](ClO4)2 (1) [L = N-(1-pyridin-2-yl-phenylidene)-N'-[2-({2-[(1-pyridin-2-ylphenylidene)amino]ethyl}amino)ethyl] ethane-1,2-diamine] (1) is reported. 1 crystallizes in P-1 space group with a = 11.9241(3) Å, b = 12.1994(3) Å and c = 13.0622(4) Å. The binding property of the complex with DNA has been investigated using absorption and emission studies, thermal melting, viscosity experiments and circular dichroism studies. The binding constant ($K_b$) and the linear Stern-Volmer quenching constant ($K_{\text{sv}}$) of the complex have been determined as $3.5 \times 10^3$M-1 and $2.73 \times 10^4$M-1, respectively. Spectroscopic and hydrodynamic investigations revealed intercalative mode of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner.

    • Author Affiliations

       

      Abhijit Pal1 Bhaskar Biswas1 2 Merry Mitra1 Subramaniyam Rajalakshmi3 Chandra Shekhar Purohit4 Soumitra Hazra5 Gopinatha Suresh Kumar5 Balachandran Unni Nair3 Rajarshi Ghosh1

      1. Department of Chemistry, The University of Burdwan, Burdwan 713 104, India
      2. Department of Chemistry, Raghunathpur College, Purulia 723 133, India
      3. Chemical Laboratory, CSIR-Central Leather Research Institute, Adayar, Chennai 600 020, India
      4. Department of Chemical Sciences, National Institute of Science Education and Research, Bhubaneswar 751 005, India
      5. Biophysical Chemistry Laboratory, Chemistry Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700 032, India
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