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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/125/05/1115-1121

    • Keywords

       

      Toddalia asiatica; Rutaceae; coumarins; alkaloid; antiplasmodial; larvicidal activities.

    • Abstract

       

      From the 𝑛-hexane, ethyl acetate and methanol extracts of Toddalia asiatica root bark were isolated eight compounds (1-8) which were identified on the basis of both spectroscopic and physical data as well as comparison with already published results. The crude extracts and isolated compounds showed moderate in vitro antiplasmodial activity against D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum. The extracts and isolates also exhibited larvicidal activities against Aedes aegypti and coumarins were identified as the active compounds.

    • Author Affiliations

       

      T Nyahanga1 J Isaac Jondiko1 L Onyango Arot Manguro1 J Atieno Orwa2

      1. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya
      2. Kenya Medical Research Institute, Centre for Traditional Medicine and Drug Research, P. O. Box 54840-00200, Nairobi, Kenya

    • Dates

       
      Published
      September 2013
      Manuscript received
      30 July 2012
      Manuscript revised
      19 March 2013
      Accepted
      4 July 2013

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      Posted on July 25, 2019

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