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https://www.ias.ac.in/article/fulltext/jcsc/125/05/1115-1121

Toddalia asiatica; Rutaceae; coumarins; alkaloid; antiplasmodial; larvicidal activities.

From the 𝑛-hexane, ethyl acetate and methanol extracts of Toddalia asiatica root bark were isolated eight compounds (1-8) which were identified on the basis of both spectroscopic and physical data as well as comparison with already published results. The crude extracts and isolated compounds showed moderate in vitro antiplasmodial activity against D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum. The extracts and isolates also exhibited larvicidal activities against Aedes aegypti and coumarins were identified as the active compounds.

T Nyahanga¹ J Isaac Jondiko¹ L Onyango Arot Manguro¹ J Atieno Orwa²

1. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya
2. Kenya Medical Research Institute, Centre for Traditional Medicine and Drug Research, P. O. Box 54840-00200, Nairobi, Kenya

Published

September 2013

Manuscript received

30 July 2012

Manuscript revised

19 March 2013

Accepted

4 July 2013