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      https://www.ias.ac.in/article/fulltext/jcsc/125/05/1115-1121

    • Keywords

       

      Toddalia asiatica; Rutaceae; coumarins; alkaloid; antiplasmodial; larvicidal activities.

    • Abstract

       

      From the 𝑛-hexane, ethyl acetate and methanol extracts of Toddalia asiatica root bark were isolated eight compounds (1-8) which were identified on the basis of both spectroscopic and physical data as well as comparison with already published results. The crude extracts and isolated compounds showed moderate in vitro antiplasmodial activity against D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum. The extracts and isolates also exhibited larvicidal activities against Aedes aegypti and coumarins were identified as the active compounds.

    • Author Affiliations

       

      T Nyahanga1 J Isaac Jondiko1 L Onyango Arot Manguro1 J Atieno Orwa2

      1. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya
      2. Kenya Medical Research Institute, Centre for Traditional Medicine and Drug Research, P. O. Box 54840-00200, Nairobi, Kenya
    • Dates

       
  • Journal of Chemical Sciences | News

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