• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/125/05/1093-1101

    • Keywords

       

      Synthesis; 4-7-dichloroquinoline; 1-3-diaminopropane; oxazolidinone; antimicrobial activity and cytotoxicity study.

    • Abstract

       

      Some 3-(3-(7-chloroquinolin-4-ylamino)propyl-2-imino-5-(4-chloro/nitro/methoxy benzylidene) oxazolidin-4-one 4(a-c) and 4-(3-(7-chloroquinolin-4-ylamino) propyl)-2(4-chloro/nitro/methoxy benzylidene)-1,6-diox-4,9 diazaspiro[4,4]nonane-3,8-dione 5(a-c) derivatives were synthesized using appropriate synthetic route. The newly prepared compounds 5a-c demonstrated inhibitory effects on the growth of a MCF7 (hormone-dependant breast carcinoma cell line), HT29 (colon carcinoma cell line on leukemia). The MCF7 cell line was found to be very susceptible towards compound 5a with IC50 values of 16 𝜇g/ml. Similarly, the HT29 cell line was found to be moderately susceptible towards compounds 5a and 5c with IC 50 values of 32 and 49 𝜇g/ml, respectively.

    • Author Affiliations

       

      Kavita Devi1 Yumna Asmat1 Meenakshi Agrawal1 Swapnil Sharma2 Jaya Dwivedi1

      1. Department of Chemistry, Banasthali University, Banasthali 304 022, India
      2. Department of Pharmacy, Banasthali University, Banasthali 304 022, India
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2017-2019 Indian Academy of Sciences, Bengaluru.