• The reaction of carbon disulphide with 𝛼-haloketones and primary amines in the presence of potassium iodide as catalyst

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    • Keywords


      carbon disulphide; 𝛼-haloketone; primary amines; potassium iodide; thiazole; nucleophilic addition.

    • Abstract


      A simple, mild and convenient method has been developed for the synthesis of 3,4,5-trialkyl-1,3-thiazole-2(3𝐻)-thione derivatives through one pot three-component reaction between a primary amine, carbon disulphide, and 𝛼-haloketone in the presence of potassium iodide at room temperature conditions. The products were obtained with excellent yield and appropriate reaction times. This reaction represents a rapid and unprecedented route to the described molecules that have biological specifications.

    • Author Affiliations


      Javad Safaei-Ghomi1 Fariba Salimi1 Ali Ramazani2

      1. Department of Chemistry, Faculty of Sciences, University of Kashan, Kashan, 51167, IR, Iran
      2. Chemistry Department, Zanjan University, P O Box 45195-313, Zanjan, Ira
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  • Journal of Chemical Sciences | News

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