• Synthesis of some novel fluoro isoxazolidine and isoxazoline derivatives using 𝑁-benzyl fluoro nitrone via cycloaddition reaction in ionic liquid

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      https://www.ias.ac.in/article/fulltext/jcsc/125/05/1071-1077

    • Keywords

       

      𝑁-Benzyl fluoro nitrone; cycloaddition reaction; fluoro isoxazolidine and isoxazolines; ionic liquid; 1,3-amino alcohol; aldehyde/ketone synthesis.

    • Abstract

       

      1-Butyl-3-methylimidazolium-based ionic liquids are found to accelerate significantly the intermolecular 1,3-dipolar cycloaddition of 𝑁-benzyl-fluoro nitrone derived in situ from 2,6-difluoro benzaldehyde and 𝑁-benzylhydroxylamine, with activated alkenes and electron deficient alkynes to afford enhanced rates and improved yields of novel isoxazolidines and isoxazolines.

    • Author Affiliations

       

      Bhaskar Chakraborty1 Govinda Prasad Luitel1

      1. Organic Chemistry Laboratory, Sikkim Government College, Gangtok 737 102, India
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