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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/125/05/1015-1027

    • Keywords

       

      Vilsmeier-Haack reagent; indoloquinolines; photosensitizer; photoinduced antibacterial activity; photo-DNA binding.

    • Abstract

       

      Angular and linear isomers of indoloquinoline are synthesized from 4-hydroxyquinolin-2(1H)-one. The use of Vilsmeier-Haack reagent on 𝑁-phenylpropionamide yielded a new versatile method for the synthesis of 2-chloro-3-methylquinoline which is utilized as precursor in the synthesis of basic camptothecin core and quinoline fused with 1,8-naphthridine. The in vivo photoinduced antibacterial activity of all the synthesized compounds has been studied. The unique photo-bioactivity of 5𝐻-indolo[3,2-𝑐]quinolin-6(11𝐻)-one is further studied under the photo-DNA cleavage analysis. Theoretical calculations for the synthesized compounds are performed to determine further credentials of the biological results.

    • Author Affiliations

       

      Malathi Mahalingam1 2 Palathurai Subramaniam Mohan1 Kasirajan Gayathri1 Ramadoss Gomathi1 3 Pushparaja Subhapriya4

      1. Department of Chemistry, Bharathiar University, Coimbatore 641 046, India
      2. Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam, India
      3. Department of Inorganic Chemistry, Madurai Kamarajar University, Madurai, India
      4. Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam 638 401, India

    • Dates

       
      Published
      September 2013
      Manuscript received
      12 December 2012
      Manuscript revised
      12 April 2013
      Accepted
      17 May 2013

    • Supplementary Material

       

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