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    • Keywords


      Corymbia maculata; flavonoid glycosides; methylated flavonoids; myrciaphenone; HPLC quantitation.

    • Abstract


      An activity-guided fractionation was used to identify the antileishmanial compounds of Corymbia maculata. The hexane, ethyl acetate and methanol extracts were active in in vitro antileishmanial assay. Twelve polyphenols including 8-demethyl eucalyptin (1), eucalyptin (2), myrciaphenone A (3), myrciaphenone B (4), quercetin-3-𝑂-𝛽-D-xylopyranoside (5), myricetin-3-𝑂-𝛼-L-rhamnopyranoside (6), quercetin-3-𝑂-𝛽-D-galactopyranoside (7), quercetin-3-𝑂-𝛽-D-glucopyranoside (8), quercetin-3-𝑂-𝛼-L-rhamnopyranoside (9), syringic acid (10), gallic acid-3-methyl ether (11), gallic acid-4-methyl ether (12) and gallic acid (13) were isolated from the active extracts. All the tested compounds except 8-demethyleucalyptin and myrciaphenone B showed strong to moderate (6.9-24.5 𝜇M) antileishmanial activity against Leishmania donovani promastigotes. An HPLC-PDA method has been developed to detect/quantify 29 compounds in the extracts of C. maculata leaves. This validated method allows simultaneous quantitation of seven flavonoids, fourteen phloroglucinols and eight other polyphenols and can be applied for qualitative as well as quantitative determination of phytoconstituents in Eucalyptus matrices.

    • Author Affiliations


      Jasmeen Sidana1 2 Dinesh Neeradi3 Alka Choudhary1 Sushma Singh3 William J Foley4 Inder Pal Singh1

      1. Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, SAS Nagar, Punjab 160 062, India
      2. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 114 441, India
      3. Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, SAS Nagar, Punjab 160 062, India
      4. Research School of Biology, The Australian National University, Canberra 0200, Australia
    • Dates

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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