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      https://www.ias.ac.in/article/fulltext/jcsc/125/01/0101-0107

    • Keywords

       

      Lithium triflate (LiOTf); three-component coupling (A3); propargylamine; C-H activation; solvent-free condition.

    • Abstract

       

      An efficient process has been developed for the synthesis of propargylamines via a threecomponent coupling reaction of aldehyde, secondary alicyclic amine and alkyne (A3) under solvent-free condition using lithium triflate (LiOTf) as expeditious reusable catalyst. This one-pot transformation generates one C-C and one C-N bond, which presumably proceeds by lithium acetylide as well as formation of iminium ion in situ and then undergoes nucleophilic addition to the iminium ion to give the propargyl amine. The solventfree condition, easy recovery of the catalyst, simple, user-friendly and quantitative yield in short time renders the protocol economic and reasonable.

    • Author Affiliations

       

      Someshwar D Dindulkar1 Baek Kwan1 Kwon Taek Lim1 Yeon Tae Jeong1

      1. Department of Image Science and Engineering, Pukyong National University, Busan 608-739, Republic of Korea
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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