• Super acid catalysed sequential hydrolysis/cycloisomerization of 𝑜-(acetylenic)benzamides under microwave condition: Synthesis, antinociceptive and antiinflammatory activity of substituted isocoumarins

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      https://www.ias.ac.in/article/fulltext/jcsc/125/01/0071-0083

    • Keywords

       

      Microwave; sequential process; isocoumarins; antinociceptive; antiinflammatory.

    • Abstract

       

      Synthesis of isocoumarins and related compounds via triflic acid promoted hydrolysis/cyclization sequence of 2-(alkynyl)benzamides under microwave condition was achieved. The substrate scope of the reaction was broad to include not only aromatic but also polyaromatic and heteroaromatic motifs, thus highlighting the significance of this methodology. One-pot operation, short reaction time, good chemical yields and excellent regioselectivity are the advantages of this protocol. All the synthesized compounds were evaluated for their antinociceptive and antiinflammatory activities using in vivo rodent models.

    • Author Affiliations

       

      Chandrasekaran Praveen1 P Dheenkumar2 P T Perumal1

      1. Organic Chemistry Division, Central Leather Research Institute (CSIR), Adyar, Chennai 600 020, India
      2. Department of Pharmaceutical Chemistry, EGS Pillay College of Pharmacy, Nagapattinam 611 002, India
    • Dates

       
  • Journal of Chemical Sciences | News

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