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      https://www.ias.ac.in/article/fulltext/jcsc/124/06/1405-1413

    • Keywords

       

      Carbohydrate; pyridyl triazole; palladium complexes; cytotoxicity.

    • Abstract

       

      Carbohydrate containing pyridyl triazole ligands, 5-deoxy-1,2-𝑂-isopropylidene-5-(4-(2-pyridyl)-1H-1,2,3-triazole-1-yl)-𝛼-D-xylofuranose (2a), 3-𝑂-Benzyl-5-deoxy-1,2-𝑂-isopropylidene-5-(4-(2-pyridyl)-1H-1,2,3-triazol-1-yl)-𝛼-D-xylofuranose (2b), methyl-5-deoxy-2,3-𝑂-isopropylidene-5-(4-(2-pyridyl)-1H-1,2,3-triazol-1-yl)-𝛽-D-ribofuranoside, (2c) and 6-deoxy-1,2:3,4-di-𝑂-isopropylidene-6-(4-(2-pyridyl)-1H-1,2,3-triazol-1-yl)-𝛼-D-galactopyranose (2d) were prepared by the `click’ reaction of 2-ethynyl pyridine with the corresponding azides. The palladium complexes were synthesised by the reaction of pyridyl triazole ligands with [Pd(COD)Cl2] in dichloromethane. All the compounds were characterized by NMR, IR, mass and elemental analysis. Structural characterization of the ligand 2a was done by X-ray crystallography. The ligands and complexes were tested for their cytotoxic activity on different cell lines like A549 (human alveolar adenocarcinoma cells), Neuro2a (mouse neuroblastoma cells), HeLa (cervical carcinoma cancer cells), MDA-MB-231 (human breast adenocarcinoma cells) and MCF7 (human breast adenocarcinoma cells). The complexes showed considerable cytotoxicity while the ligands were non-toxic on the tested cell lines.

    • Author Affiliations

       

      S Bhavya Deepthi1 Rajiv Trivedi1 P Sujitha2 C Ganesh Kumar2 B Sridhar3 Suresh K Bhargava4 5

      1. Organometallic Chemistry Group, Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India
      2. Chemical Biology Laboratory, Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India
      3. Laboratory of X-Ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India
      4. RMIT-IICT Research Centre, Indian Institute of Chemical Technology, Hyderabad 500 607, India
      5. Advanced Materials and Industrial Chemistry Group, School of Applied Sciences, Royal Melbourne Institute of Technology University, Melbourne, VIC, 3001, Australia
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    • Supplementary Material

       
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