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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/124/05/1043-1048

    • Keywords

       

      Thioquinazolinones; oximes; oxime carbamates; phenyl isocyanate; hydroxylamine hydrochloride.

    • Abstract

       

      S-alkylation of 3-aryl-2-thioquinazolin-4(3H)-one (1) with chloroacetone gave 2-(propanonyl thio)-3-arylquinazol-4(3H)ones (2). Further, the treatment of compound (2) with hydroxylamine hydrochloride gave the corresponding oximes (3) which on reaction with phenyl isocyanate in THF yielded corresponding oxime carbamates 4. The synthesized compounds have been confirmed using IR and 1H NMR, mass spectral data together with elemental analysis. All newly synthesized compounds have been tested for their antibacterial and antifungal activities.

    • Author Affiliations

       

      Suresh S Patil1 Swati D Jadhav1 M B Deshmukh2

      1. Organic Research Laboratory, Padmabhushan Dr. Vasantraodada Patil College, Tasgaon, Dist. Sangli 416 312, India
      2. Department of Chemistry, Shivaji University, Kolhapur 416 004, India
    • Dates

       
  • Journal of Chemical Sciences | News

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