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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/124/04/0847-0855

    • Keywords

       

      3,4-Dihydropyrimidine 2-thione; thiazolopyrimidine; crystal structure; antibacterial and antifungal activity.

    • Abstract

       

      Different substituted diesters of thiazolopyrimidine were prepared by the treatment of 3,4 dihydropyrimidine2-thione with 𝛼-haloesters using ethanol under reflux condition affording 71-85% yield. IR, 1HNMR, 13CNMR and elemental analyses were used for the characterization of these compounds. The crystal and molecular structure of one of the product, 5-phenyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-2,6-dicarboxylic acid diethyl ester (3e) was verified by single crystal X-ray diffraction method. The antimicrobial activity was evaluated against four bacterial strains and one fungal species. Few of the derivatives exhibited antibacterial and antifungal activities.

    • Author Affiliations

       

      H Nagarajaiah1 I M Khazi2 Noor Shahina Begum1

      1. Department of Chemistry, Bangalore University, Bangalore 560 001, India
      2. Department of Chemistry, Karnatak University, Dharwad 580 003, India

    • Dates

       
      Published
      July 2012
      Manuscript received
      21 September 2011
      Manuscript revised
      9 February 2012
      Accepted
      26 March 2012

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