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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/124/03/0609-0624

    • Keywords

       

      Microwave; one-pot synthesis; benzothiazoles; benzoxazoles; analgesic activity.

    • Abstract

       

      Microwave-assisted synthesis of benzothiazole and benzoxazole libraries via PIFA promoted cyclocondensation of 2-aminothiophenols/2-aminophenols with aldehydes under one-pot condition in good to excellent yields was achieved. Twenty compounds have been investigated for their analgesic activity and showed moderate to good activity.

    • Author Affiliations

       

      C Praveen1 A Nandakumar1 P Dheenkumar2 D Muralidharan1 P T Perumal1

      1. Organic Chemistry Division, Central Leather Research Institute (CSIR), Adyar, Chennai 600 020, India
      2. Department of Pharmaceutical Chemistry, EGS Pillay College of Pharmacy, Nagapattinam 611 002, India

    • Dates

       
      Published
      May 2012
      Manuscript received
      28 August 2011
      Manuscript revised
      19 November 2011
      Accepted
      2 December 2011

    • Supplementary Material

       

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