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Microwave; one-pot synthesis; benzothiazoles; benzoxazoles; analgesic activity.

Microwave-assisted synthesis of benzothiazole and benzoxazole libraries via PIFA promoted cyclocondensation of 2-aminothiophenols/2-aminophenols with aldehydes under one-pot condition in good to excellent yields was achieved. Twenty compounds have been investigated for their analgesic activity and showed moderate to good activity.

C Praveen¹ A Nandakumar¹ P Dheenkumar² D Muralidharan¹ P T Perumal¹

1. Organic Chemistry Division, Central Leather Research Institute (CSIR), Adyar, Chennai 600 020, India
2. Department of Pharmaceutical Chemistry, EGS Pillay College of Pharmacy, Nagapattinam 611 002, India

Published

May 2012

Manuscript received

28 August 2011

Manuscript revised

19 November 2011

Accepted

2 December 2011

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