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    • Keywords


      Phthalans; regioselectivity; antidepressant; tail suspension test; forced swim test; molecular docking.

    • Abstract


      3-Alkylidene-1,3-dihydroisobenzofurans exhibited moderate antidepressant activity as evaluated by forced swim and tail suspension test methods. Virtual screening was carried out by docking the designed compounds into the serotonin binding sites of arabinase protein to predict the analogue binding mode of the compounds to the SSRIs.

    • Author Affiliations


      C Praveen1 C Iyyappan2 K Girija2 K Suresh Kumar3 P T Perumal1

      1. Organic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020, India
      2. Department of Pharmaceutical Chemistry, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry 605 006, India
      3. Bioinformatics Centre, Pondicherry University, Puducherry 605 014, India
    • Dates

    • Supplementary Material

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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