• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/124/02/0437-0449

    • Keywords

       

      Ammonium compounds; antimicrobial activity; chromenones; quinolinones.

    • Abstract

       

      A series of novel ammonium derivatives were synthesized and examined for their antimicrobial efficacy. Comparison of antimicrobial spectrum revealed that compounds 9, 11, 16 and 23 had strong potential against pathogens in vitro. Cytotoxicity results showed compound 9 to be least toxic, it is non-toxic to A549 and U87 cells in MTT assay and exhibits marginal toxicity (15-20%) to human erythrocytes at a concentration of 1000 𝜇g/ml as compared to 100% lysis of cells by 31.25 𝜇g/ml of the standard drug amphotericin B. This compound has MIC values in the range of 1.95-31.25 𝜇g/disc in DDA against different pathogens and may considered to be an important lead antimicrobial molecule for further exploration.

    • Author Affiliations

       

      Shilpi Gupta1 Seema Singh2 3 Abha Kathuria1 Manish Kumar2 Sweta Sharma1 4 Ram Kumar2 Virinder S Parmar1 Bharat Singh2 Anjali Gupta1 Erik Van Der Eycken4 Gainda L Sharma2 Sunil K Sharma1

      1. Department of Chemistry, University of Delhi, Delhi 110 007, India
      2. Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110 007, India
      3. Department of Biotechnology, Pune University, Pune 411 007, India
      4. Katholieke Universiteit Leuven (K.U.Leuven), Celestijnenlaan 200F, 3001, Leuven, Belgium
    • Dates

       
  • Journal of Chemical Sciences | News

© 2021-2022 Indian Academy of Sciences, Bengaluru.