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    • Keywords


      Haloamines; aziridines; enantioselective; Lewis acid; nucleophilic ring opening; quaternary ammonium salts.

    • Abstract


      Quaternary ammonium salt mediated highly regioselective ring opening of aziridines with zinc(II) halides to racemic and non-racemic 𝛽-halo amines in excellent yield and selectivity is described. The reaction proceeds via an SN2-type pathway and the partial racemization of the starting substrate and the product was effectively controlled by using quaternary ammonium salts to afford the enantioenriched products (er up to 95:5).

    • Author Affiliations


      Manas K Ghorai1 Deo Prakash Tiwari1 Amit Kumar1 Kalpataru Das1

      1. Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India
    • Dates

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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