An intramolecular, alkyne Prins type cyclization of vinylogous carbonates derived from 𝑜-alkynyl phenols is developed for the stereoselective construction of trans-2,3-disubstituted dihydrobenzofuran derivatives. Strong Lewis acids like TMSOTf catalyse this reaction efficiently. The presence of mildly electron donating groups on aryl rings increases the efficiency of the reaction.
Volume 132, 2020
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