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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/123/05/0657-0666

    • Keywords

       

      1,2,4-Triazole; Schiff base; Mg(ClO4)2; azetidinone; solvent-free; drug score; MIC.

    • Abstract

       

      An efficient green approach to the synthesis of Schiff bases (11-21) of 1-amino-2-aryl-3-oxo-1,2,4-triazoles (1-3) have been reported under Mg(ClO4)2 as catalyst followed by the reaction with chloroacetyl chloride in solvent-free conditions to yield the azetidinones (22-32) with excellent yields. The synthesized compounds were evaluated for the extent of penetration into biological membranes ($clogP$), drug-likeliness and finally drug score was calculated and also screened for antitubercular and antimicrobial activities.

    • Author Affiliations

       

      Tasneem Taj1 Ravindra R Kamble1 Tegginamath Gireesh1 Bharathi V Badami1

      1. PG Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India

    • Dates

       
      Published
      September 2011
      Manuscript received
      15 September 2010
      Manuscript revised
      24 March 2011
      Accepted
      6 April 2011

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