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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/123/04/0459-0466

    • Keywords

       

      benzofuran-3-ol; resolution; pentolactone.

    • Abstract

       

      A new method for the preparation of enantiopure 2,2-disubstituted 2,3-dihydro-benzofuran-3-ols is described. A short synthesis is designed for obtaining various 2,2-disubstitued benzofuran-3-ols as racemic mixtures of the two possible syn and anti diastereoisomers, which can be separated after silylation. The major racemic anti isomers were transesterified using (R)-pentolactone, allowing separation of the pure enantiomers.

    • Author Affiliations

       

      Cédric Charrier1 Philippe Bertrand1

      1. Synthèse et Réactivité des Substances Naturelles, CNRS UMR 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, Poitiers, 86022, France

    • Dates

       
      Published
      July 2011
      Manuscript received
      23 July 2010
      Manuscript revised
      22 April 2011
      Accepted
      19 May 2011

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