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    • Keywords


      benzofuran-3-ol; resolution; pentolactone.

    • Abstract


      A new method for the preparation of enantiopure 2,2-disubstituted 2,3-dihydro-benzofuran-3-ols is described. A short synthesis is designed for obtaining various 2,2-disubstitued benzofuran-3-ols as racemic mixtures of the two possible syn and anti diastereoisomers, which can be separated after silylation. The major racemic anti isomers were transesterified using (R)-pentolactone, allowing separation of the pure enantiomers.

    • Author Affiliations


      Cédric Charrier1 Philippe Bertrand1

      1. Synthèse et Réactivité des Substances Naturelles, CNRS UMR 6514, Université de Poitiers, 40 Avenue du Recteur Pineau, Poitiers, 86022, France
    • Dates

  • Journal of Chemical Sciences | News

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