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    • Keywords


      Indeno[1,2-𝑑]pyrimidine-2-thiones; multicomponent reaction; microwave irradiation; antibacterial activity.

    • Abstract


      A simple and efficient method has been developed for the synthesis of series of 4-aryl-1,3,4,5-tetrahydro-2𝐻-indeno[1,2-𝑑]pyrimidine-2-thiones through Biginelli’s one-pot multicomponent condensation reaction via microwave irradiations. Then, these thiones were converted to their S-alkylated/aralkylated derivatives. The prepared heterocyclic products were structurally confirmed by analytical and spectral data and evaluated for their antibacterial activities. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The compound 2-(Ethylthio)-4-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1𝐻-indeno[1,2-𝑑]pyrimidines 4b have shown antibacterial activity towards all the seven clinical isolates used.

    • Author Affiliations


      Ramandeep Kaur1 Monika Bansal1 Balbir Kaur1 Tulika Mishra2 Aruna Bhatia2

      1. Department of Chemistry, Punjabi University, Patiala 147002, India
      2. Department of Biotechnology, Punjabi University, Patiala 147002, India
    • Dates

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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