Alkylation of dipotassium 2-nitro-1,1-ethylenedithiolate 1 with ethyl 4-chloroacetoacetate 6 in a mixture of MeOH-H2O (2:1) furnished highly functionalized 3-nitrothiophene 5. Pechmann condensation of 5 with 2-hydroxybenzaldehydes 8a-i, 10 furnished coumarin-3-nitrothiophene conjugates 9a-i, 11.
Volume 132, 2019
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