• Nitroketene dithioacetal chemistry: Synthesis of coumarins incorporating nitrothiophene moiety

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    • Keywords


      Nitroketenedithioacetals; 3-nitrothiophenes; 2-hydroxy benzaldehydes; coumarins; Pechmann condensation.

    • Abstract


      Alkylation of dipotassium 2-nitro-1,1-ethylenedithiolate 1 with ethyl 4-chloroacetoacetate 6 in a mixture of MeOH-H2O (2:1) furnished highly functionalized 3-nitrothiophene 5. Pechmann condensation of 5 with 2-hydroxybenzaldehydes 8a-i, 10 furnished coumarin-3-nitrothiophene conjugates 9a-i, 11.

    • Author Affiliations


      H Surya Prakash Rao1 K Vasantham1

      1. Department of Chemistry, Pondicherry University, Pondicherry 605 014, India
    • Dates

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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