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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/123/03/0335-0341

    • Keywords

       

      Oxazolone scaffold; acetyl glycine; hypoglycemic activity; antiinflammatory.

    • Abstract

       

      A series of ten novel (2a-j) 4-arylidine 2-[4-methoxy phenyl] oxazol-5-one derivatives were synthesized and assayed in vivo to investigate their antidiabetic activities by streptozotocin-induced model in rat. These derivatives showed considerable biological efficacy when compared to rosiglitazone, a potent and wellknown antidiabetic agent as a reference drug. All the compounds were effective, amongst them 2d shows more prominent activity at 50 mg/k.g.p.o. The experimental results are statistically significant at P < 0.01 level.

    • Author Affiliations

       

      G Mariappan1 B P Saha1 Sriparna Datta1 Deepak Kumar1 P K Haldar2

      1. Department of Medicinal Chemistry, Himalayan Pharmacy Institute, East Sikkim 737 136, India
      2. Department of Pharmacology, Himalayan Pharmacy Institute, East Sikkim 737 136, India
    • Dates

       
  • Journal of Chemical Sciences | News

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