A simple, efficient and a versatile method for the synthesis of 5-substituted-1𝐻-tetrazoles by a [3+2]-cycloaddition reaction of arylnitriles with sodium azide in DMF using ZrOCl2·8 H2O as catalyst has been developed. The reactions work well at 100°C and give the desired products in excellent yield. The examples studied include arylnitriles having electron donating as well as electron releasing groups on the arene nucleus.
Volume 134, 2022
Continuous Article Publishing mode
Click here for Editorial Note on CAP Mode