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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/122/06/0833-0838

    • Keywords

       

      Flocoumafen; intramolecular ring cyclization; coupling reaction, NO-generation; neurotoxicity.

    • Abstract

       

      Simple synthesis and biological properties of flocoumafen 1 and its structural isomers are described. The key synthetic strategies involve Knoevenagel condensation, Grignard reaction, intramolecular ring cyclization and coupling reaction. Flocoumafen 1 was easily separated into cis and trans forms using flash column chromatography. They were then evaluated for suppression of LPS-induced NO generation and anti-excitotoxicity in vitro. It was found that the trans-flocoumafen was potent suppressor of NO generation with the concentration of 10 𝜇M in vitro, while no significant effect for neurotoxicity in cultured cortical neurons.

    • Author Affiliations

       

      Jae-Chul Jung1 Soyong Jang1 Seikwan Oh1 Oee-Sook Park2

      1. Department of Neuroscience, Ewha Global Challenge, BK21 and Medical Research Institute, School of Medicine, Ewha Womans University, Seoul 158-710, South Korea
      2. Department of Chemistry, Institute for Basic Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 361-763, Chungbuk, Korea

    • Dates

       
      Published
      November 2010
      Manuscript received
      13 January 2010
      Manuscript revised
      22 March 2010
      Accepted
      22 June 2010

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